IMBRUVICA® for Previously Treated Adult cGVHDIMBRUVICA® for Previously Treated Adult cGVHD

IMBRUVICA® (ibrutinib)
for Previously Treated
Adult cGVHD

HomecGVHDIMBRUVICA® for Adult cGVHD

IMBRUVICA® Is an Oral, Once-Daily cGVHD Medication That May Help When Other Systemic Therapies Have Failed1

IMBRUVICA® is the first FDA-approved therapy for adult chronic graft versus host disease (cGVHD) patients who have already been treated with other systemic therapies

2 out of 3
patients responded to IMBRUVICA®

Patients who aren’t getting results with steroid therapy have another option1

In a trial of previously treated patients, 2 out of 3 patients (28 of 42 patients enrolled in the study) had a response with IMBRUVICA®, which means they showed improvement. Almost half of patients (20 of 42) in the trial had a response to IMBRUVICA® that lasted for at least 20 weeks.

What you should know about the side effects of IMBRUVICA®

IMBRUVICA® may cause serious side effects, including1:

  • Bleeding problems (hemorrhage)

  • Infections

  • Heart rhythm problems (ventricular arrhythmias, atrial fibrillation, and atrial flutter), heart failure and death

  • High blood pressure (hypertension)

  • Decrease in blood cell counts

  • Second primary cancers

  • Liver problems

  • Tumor lysis syndrome (TLS)†

†TLS is a disorder caused by the fast breakdown of cancer cells, which can lead to kidney failure and other abnormalities.

 

The most common side effects in the adult cGVHD clinical trial were1:

  • Tiredness
  • Muscle spasms
  • Bruising
  • Nausea
  • Diarrhea
  • Bleeding (hemorrhage)
  • Low platelet counts
  • Low red blood cell count
  • Mouth sores (stomatitis)
  • Pneumonia

In the adult cGVHD clinical trial, nearly 1 in 4 patients stopped taking IMBRUVICA® because of side effects.1

This is not a complete list of side effects. Others may occur. Tell your doctor if you think you are experiencing side effects.

Many cGVHD resources, one location

Watch a video on how to dose liquid IMBRUVICA® for children. Plus, access educational information, support communities, and more.

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IMBRUVICA® By Your Side Patient Support Program

Starting IMBRUVICA®?

Get information and resources to support you along your treatment journey.*

Explore Support Options

IMBRUVICA® By Your Side patient support program is not intended to provide medical advice, replace prescribed treatment plans, or provide treatment or case management services. Patients are advised to talk to their healthcare provider and treatment team about any medical decisions and concerns they may have. By Your Side Registered Nurses are provided by Johnson & Johnson and its affiliates and Pharmacyclics LLC, an AbbVie Company, and do not work under the direction of your healthcare professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.

Reference: 1. IMBRUVICA® (ibrutinib) Prescribing Information.