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How to take once-daily IMBRUVICA®

Adults

Tablets or capsules give you the freedom to take at home or wherever you may be.

Children

Talk to your doctor about the dose option and dose amount that is right for your child.

Select an indication to learn more about dosing.

    CLL/SLL: Adults

    IMBRUVICA® is dosed once a day as either a single 420-mg tablet or three 140-mg capsules.

    IMBRUVICA® tablets come in a blister pack

    Take one 420-mg IMBRUVICA® tablet by mouth, at the same time each day with a glass of water.

      It contains 28 tablets (a 4-week supply)

      Each tablet is identical

      Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions.

      IMBRUVICA® capsules come in a bottle

      Take all three 140-mg IMBRUVICA® capsules by mouth, at the same time each day with a glass of water.

        The bottles contain a 30-day supply based on recommended dosing

        Each capsule is identical

        Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you. 

          WM: Adults

          IMBRUVICA® is dosed once a day as either a single 420-mg tablet or three 140-mg capsules.

          IMBRUVICA® tablets come in a blister pack

          Take one 420-mg IMBRUVICA® tablet by mouth, at the same time each day with a glass of water.

            It contains 28 tablets (a 4-week supply)

            Each tablet is identical

            Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions.

            IMBRUVICA® capsules come in a bottle

            Take all three 140-mg IMBRUVICA® capsules by mouth, at the same time each day with a glass of water.

              The bottles contain a 30-day supply based on recommended dosing

              Each capsule is identical

              Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you. 

                Previously treated MZL: Adults

                IMBRUVICA® is dosed once a day as either a single 560-mg tablet or four 140-mg capsules.

                IMBRUVICA® tablets come in a blister pack

                Take one 560-mg IMBRUVICA® tablet by mouth, at the same time each day with a glass of water.

                  It contains 28 tablets (a 4-week supply)

                  Each tablet is identical

                  Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions.

                  IMBRUVICA® capsules come in a bottle

                  Take all four 140-mg IMBRUVICA® capsules by mouth, at the same time each day with a glass of water.

                    The bottles contain a 30-day supply based on recommended dosing

                    Each capsule is identical

                    Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you. 

                      Previously treated MCL: Adults

                      IMBRUVICA® is dosed once a day as either a single 560-mg tablet or four 140-mg capsules.

                      IMBRUVICA® tablets come in a blister pack

                      Take one 560-mg IMBRUVICA® tablet by mouth, at the same time each day with a glass of water.

                        It contains 28 tablets (a 4-week supply)

                        Each tablet is identical

                        Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions.

                        IMBRUVICA® capsules come in a bottle

                        Take all four 140-mg IMBRUVICA® capsules by mouth, at the same time each day with a glass of water.

                          The bottles contain a 30-day supply based on recommended dosing

                          Each capsule is identical

                          Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you. 

                            Previously treated cGVHD: Adults

                            IMBRUVICA® is dosed once a day as either a single 420-mg tablet or three 140-mg capsules.

                            IMBRUVICA® tablets come in a blister pack

                            Take one 420-mg IMBRUVICA® tablet by mouth, at the same time each day with a glass of water.

                              It contains 28 tablets (a 4-week supply)

                              Each tablet is identical

                              Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions.

                              IMBRUVICA® capsules come in a bottle

                              Take all three 140-mg IMBRUVICA® capsules by mouth, at the same time each day with a glass of water.

                                The bottles contain a 30-day supply based on recommended dosing

                                Each capsule is identical

                                Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you. 

                                  Previously treated cGVHD: Children (1 year and older)

                                  Talk to your doctor about dose options and the correct dose amount (based on the child's weight and height).

                                  IMBRUVICA® oral suspension comes in a bottle

                                  You may use this step-by-step guide for preparing and dosing IMBRUVICA® oral suspension (liquid IMBRUVICA®).

                                    Glass bottle with child-resistant screw cap

                                    2 reusable/washable oral dosing syringes

                                    Dose amount is dependent on the child's weight, height, and age

                                    IMBRUVICA® tablets come in a blister pack

                                    Take the 420-mg IMBRUVICA® tablet by mouth, at the same time each day with a glass of water.

                                      It contains 28 tablets (a 4-week supply)

                                      Each tablet is identical

                                      Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions.

                                      IMBRUVICA® capsules come in a bottle

                                      Take 140-mg IMBRUVICA® capsules by mouth, at the same time each day with a glass of water.

                                        The bottles contain a 30-day supply based on recommended dosing

                                        Each capsule is identical

                                        Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you. 

                                        Also important to know:

                                        • Take IMBRUVICA® exactly as your healthcare provider tells you to take it.
                                        • Take IMBRUVICA® 1 time a day at about the same time each day.

                                        IMBRUVICA® comes as capsules, tablets, and oral suspension.

                                        • If your healthcare provider prescribes IMBRUVICA® capsules or tablets:
                                          • Swallow IMBRUVICA® capsules or tablets whole with a glass of water.
                                          • Do not open, break, or chew IMBRUVICA® capsules.
                                          • Do not cut, crush, or chew IMBRUVICA® tablets.
                                        • If your healthcare provider prescribes IMBRUVICA® oral suspension:
                                          • See the detailed Instructions for Use that comes with IMBRUVICA® oral suspension for information about the correct way to give a dose to your child. If you have questions about how to give IMBRUVICA® oral suspension, talk to your healthcare provider.
                                          • Do not use if the carton seal is broken or missing.
                                        • If you miss a dose of IMBRUVICA® take it as soon as you remember on the same day. Take your next dose of IMBRUVICA® at your regular time on the next day. Do not take extra doses of IMBRUVICA® to make up for a missed dose.
                                        • If you take too much IMBRUVICA®, call your healthcare provider or go to the nearest hospital emergency room right away.

                                        Call your doctor or pharmacist if you have any questions.

                                        While taking IMBRUVICA®

                                        • Do not drink grapefruit juice 
                                        • Do not eat grapefruit
                                        • Do not eat Seville oranges, often used in marmalade

                                        These products may increase the amount of IMBRUVICA® in your blood.

                                        Storing IMBRUVICA®

                                        • Store IMBRUVICA® capsules and tablets at room temperature between 68°F and 77°F (20°C and 25°C)
                                        • Keep IMBRUVICA® capsules in the original container with the lid tightly closed
                                        • Keep IMBRUVICA® tablets in the original carton
                                        • Store IMBRUVICA® oral suspension bottle between 36°F and 77°F (2°C and 25°C). Do not freeze
                                        • Use IMBRUVICA® oral suspension within 60 days after opening the bottle. Throw away (discard) any unused portion 60 days after opening

                                        Keep IMBRUVICA® and all medicines out of the sight and reach of children.

                                        Talk to your doctor about the medications you’re taking

                                        Tell your doctor about any other medications you are taking, including prescriptions or over-the-counter medications, vitamins, and herbal supplements. Taking IMBRUVICA® with certain other medicines may affect how IMBRUVICA® works and can cause side effects.

                                        Taking IMBRUVICA® and have questions?

                                        Call us at 1-888-YourSide (1-888-968-7743) or click below to learn more.

                                        Learn More

                                        Some ways to stay on track with your treatment

                                        It’s important to take your medicines exactly as directed by your doctor and creating a routine may help with your IMBRUVICA® treatment. Here are some ways to help you stay on course:

                                        Link it. Take your medicine at the same time as something else you do on a daily basis, like walking the dog or brushing your teeth.

                                        Hear it. Set a daily alarm on your phone, watch, or clock to go off when you need to take IMBRUVICA®.

                                        See it. Use reminder notes or put your IMBRUVICA® container in a place you will see it (like next to your bed). Keep IMBRUVICA® out of the reach of children.

                                        Use your tools. Use tools, such as an app on your smartphone, or a calendar, to set reminders for yourself.

                                        Do not stop taking IMBRUVICA® without talking to your doctor. Always take IMBRUVICA® exactly as your doctor prescribes.

                                        Reference:

                                        1. IMBRUVICA® (ibrutinib) Prescribing Information.

                                        IMPORTANT SIDE EFFECT INFORMATION

                                        Before taking IMBRUVICA®, tell your healthcare provider about all of your medical conditions, including if you:

                                        • have had recent surgery or plan to have surgery. Your healthcare provider may stop IMBRUVICA® for any planned medical, surgical, or dental procedure.
                                        • have bleeding problems
                                        • have or had heart rhythm problems, smoke, or have a medical condition that increases your risk of heart disease, such as high blood pressure, high cholesterol, or diabetes
                                        • have an infection
                                        • have liver problems
                                        • are pregnant or plan to become pregnant. IMBRUVICA® can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with IMBRUVICA®. Tell your healthcare provider if you are pregnant or think you may be pregnant during treatment with IMBRUVICA®. 
                                          • Females who are able to become pregnant should use effective birth control (contraception) during treatment with IMBRUVICA® and for 1 month after the last dose.
                                          • Males with female partners who are able to become pregnant should use effective birth control, such as condoms, during treatment with IMBRUVICA® and for 1 month after the last dose.
                                        • are breastfeeding or plan to breastfeed. Do not breastfeed during treatment with IMBRUVICA® and for 1 week after the last dose. 

                                        Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking IMBRUVICA® with certain other medicines may affect how IMBRUVICA® works and can cause side effects.

                                        How should I take IMBRUVICA®?

                                        • Take IMBRUVICA® exactly as your healthcare provider tells you to take it.
                                        • Take IMBRUVICA® 1 time a day at about the same time each day.

                                          IMBRUVICA® comes as capsules, tablets, and oral suspension.

                                        • If your healthcare provider prescribes IMBRUVICA® capsules or tablets:
                                          • Swallow IMBRUVICA® capsules or tablets whole with a glass of water.
                                          • Do not open, break, or chew IMBRUVICA® capsules.
                                          • Do not cut, crush, or chew IMBRUVICA® tablets.
                                        • If your healthcare provider prescribes IMBRUVICA® oral suspension:
                                          • See the detailed Instructions for Use that comes with IMBRUVICA® oral suspension for information about the correct way to give a dose to your child. If you have questions about how to give IMBRUVICA® oral suspension, talk to your healthcare provider.
                                          • Do not use if the carton seal is broken or missing.
                                        • If you miss a dose of IMBRUVICA® take it as soon as you remember on the same day. Take your next dose of IMBRUVICA® at your regular time on the next day. Do not take extra doses of IMBRUVICA® to make up for a missed dose.
                                        • If you take too much IMBRUVICA® call your healthcare provider or go to the nearest hospital emergency room right away. 

                                        What should I avoid while taking IMBRUVICA®?

                                        • You should not drink grapefruit juice, eat grapefruit, or eat Seville oranges (often used in marmalades) during treatment with IMBRUVICA®. These products may increase the amount of IMBRUVICA® in your blood.

                                        What are the possible side effects of IMBRUVICA®?

                                        IMBRUVICA® may cause serious side effects, including:

                                        • Bleeding problems (hemorrhage) are common during treatment with IMBRUVICA®, and can also be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs of bleeding, including: blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding, or bleeding that is severe or that you cannot control, vomit blood or vomit looks like coffee grounds, cough up blood or blood clots, increased bruising, dizziness, weakness, confusion, change in your speech, or a headache that lasts a long time or severe headache.  
                                        • Infections can happen during treatment with IMBRUVICA®. These infections can be serious and may lead to death. Tell your healthcare provider right away if you have fever, chills, weakness, confusion, or other signs or symptoms of an infection during treatment with IMBRUVICA®.
                                        • Heart problems. Serious heart rhythm problems (ventricular arrhythmias, atrial fibrillation and atrial flutter), heart failure and death have happened in people treated with IMBRUVICA®, especially in people who have an infection, an increased risk for heart disease, or have had heart rhythm problems in the past. Your heart function will be checked before and during treatment with IMBRUVICA®. Tell your healthcare provider if you get any symptoms of heart problems, such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, swelling of the feet, ankles or legs, chest discomfort, or you faint. If you develop any of these symptoms, your healthcare provider may do tests to check your heart and may change your IMBRUVICA® dose.
                                        • High blood pressure (hypertension). New or worsening high blood pressure has happened in people treated with IMBRUVICA®. Your healthcare provider may start you on blood pressure medicine or change current medicines to treat your blood pressure.
                                        • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with IMBRUVICA®, but can also be severe. Your healthcare provider should do monthly blood tests to check your blood counts.
                                        • Second primary cancers. New cancers have happened during treatment with IMBRUVICA®, including cancers of the skin or other organs.
                                        • Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer cells. TLS can cause kidney failure and the need for dialysis treatment, abnormal heart rhythm, seizure, and sometimes death. Your healthcare provider may do blood tests to check you for TLS.

                                        The most common side effects of IMBRUVICA® in adults with B-cell malignancies (MCL, CLL/SLL, WM and MZL) include:

                                        • diarrhea
                                        • tiredness
                                        • muscle and bone pain
                                        • rash
                                        • bruising

                                        The most common side effects of IMBRUVICA® in adults or children 1 year of age and older with cGVHD include:

                                        • tiredness
                                        • low red blood cell count (anemia)
                                        • bruising
                                        • diarrhea
                                        • low platelet count
                                        • muscle and joint pain
                                        • fever
                                        • muscle spasms
                                        • mouth sores (stomatitis)
                                        • bleeding
                                        • nausea 
                                        • stomach pain 
                                        • pneumonia
                                        • headache

                                        Diarrhea is a common side effect in people who take IMBRUVICA®. Drink plenty of fluids during treatment with IMBRUVICA® to help reduce your risk of losing too much fluid (dehydration) due to diarrhea. Tell your healthcare provider if you have diarrhea that does not go away.

                                        These are not all the possible side effects of IMBRUVICA®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

                                        General information about the safe and effective use of IMBRUVICA®

                                        Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use IMBRUVICA® for a condition for which it was not prescribed. Do not give IMBRUVICA® to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about IMBRUVICA® that is written for health professionals.

                                        Please see the full Important Product Information.

                                        USES

                                        What is IMBRUVICA® (ibrutinib)?

                                        IMBRUVICA® (ibrutinib) is a prescription medicine used to treat:

                                        • Adults with mantle cell lymphoma (MCL) who have received at least one prior treatment.
                                        • Adults with chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL).
                                        • Adults with chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) with 17p deletion.
                                        • Adults with Waldenström’s macroglobulinemia (WM).
                                        • Adults with marginal zone lymphoma (MZL) who require a medicine by mouth or injection (systemic therapy) and have received a certain type of prior treatment.
                                        • Adults and children 1 year of age and older with chronic graft versus host disease (cGVHD) after failure of 1 or more lines of systemic therapy.

                                        It is not known if IMBRUVICA® is safe and effective in children under 1 year of age.

                                        IMPORTANT SIDE EFFECT INFORMATION

                                        USES