For patients 1 to less than 12 years of age, talk to your doctor about dose options and the correct dose amount (based on the child's weight and height).
IMBRUVICA® (ibrutinib) Dosing Guide
How to take once-daily IMBRUVICA®
IMBRUVICA® is an oral, once-a-day treatment that gives you the freedom to take with a glass of water, with or without meals, on a schedule that meets your needs. IMBRUVICA® provides the ease of oral dosing—so you can focus more on what really matters.
CLL/SLL: Adults
IMBRUVICA® is dosed once a day as a single 420-mg tablet, three 140-mg capsules, or 6 mL of liquid oral suspension (6 mL=420 mg). If your doctor prescribes liquid IMBRUVICA® oral suspension, refer to the detailed Instructions for Use that comes with IMBRUVICA® oral suspension.
IMBRUVICA® tablets
come in a blister pack
Take one 420-mg IMBRUVICA® tablet by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® tablets blister pack
It contains 28 tablets (a 4-week supply)
Each tablet is identical
Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions
OR
IMBRUVICA® capsules come in a bottle
Take all three 140-mg IMBRUVICA® capsules by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® capsules bottle
The bottle contains a 30-day supply based on recommended dosing
Each capsule is identical
OR
IMBRUVICA® oral suspension comes in a bottle
Take 6 mL of liquid IMBRUVICA® oral suspension by mouth at about the same time each day. Make sure to drink water after swallowing the dose.
Learn more about the IMBRUVICA® oral suspension bottle
Supplied in a glass bottle with child-resistant screw cap
The bottle comes with two 3-mL oral syringes
Each mL of liquid oral suspension contains 70 mg of IMBRUVICA®
Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you.
WM: Adults
IMBRUVICA® is dosed once a day as a single 420-mg tablet, three 140-mg capsules, or 6 mL of liquid oral suspension (6 mL=420 mg). If your doctor prescribes liquid IMBRUVICA® oral suspension, refer to the detailed Instructions for Use that comes with IMBRUVICA® oral suspension.
IMBRUVICA® tablets
come in a blister pack
Take one 420-mg IMBRUVICA® tablet by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® tablets blister pack
It contains 28 tablets (a 4-week supply)
Each tablet is identical
Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions
OR
IMBRUVICA® capsules come in a bottle
Take all three 140-mg IMBRUVICA® capsules by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® capsules bottle
The bottle contains a 30-day supply based on recommended dosing
Each capsule is identical
OR
IMBRUVICA® oral suspension comes in a bottle
Take 6 mL of liquid IMBRUVICA® oral suspension by mouth at about the same time each day. Make sure to drink water after swallowing the dose.
Learn more about the IMBRUVICA® oral suspension bottle
Supplied in a glass bottle with child-resistant screw cap
The bottle comes with two 3-mL oral syringes
Each mL of liquid oral suspension contains 70 mg of IMBRUVICA®
Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you.
Previously treated cGVHD: Adults
IMBRUVICA® is dosed once a day as a single 420-mg tablet, three 140-mg capsules, or 6 mL of liquid oral suspension (6 mL=420 mg). If your doctor prescribes liquid IMBRUVICA® oral suspension, refer to the detailed Instructions for Use that comes with IMBRUVICA® oral suspension.
IMBRUVICA® tablets
come in a blister pack
Take one 420-mg IMBRUVICA® tablet by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® tablets blister pack
It contains 28 tablets (a 4-week supply)
Each tablet is identical
Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions
OR
IMBRUVICA® capsules come in a bottle
Take all three 140-mg IMBRUVICA® capsules by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® capsules bottle
The bottle contains a 30-day supply based on recommended dosing
Each capsule is identical
OR
IMBRUVICA® oral suspension comes in a bottle
Take 6 mL of liquid IMBRUVICA® oral suspension by mouth at about the same time each day. Make sure to drink water after swallowing the dose.
Learn more about the IMBRUVICA® oral suspension bottle
Supplied in a glass bottle with child-resistant screw cap
The bottle comes with two 3-mL oral syringes
Each mL of liquid oral suspension contains 70 mg of IMBRUVICA®
Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you.
Previously treated cGVHD: Children age 12 years and older
IMBRUVICA® is dosed once a day as a single 420-mg tablet, three 140-mg capsules, or 6 mL of liquid oral suspension (6 mL=420 mg). If your doctor prescribes liquid IMBRUVICA® oral suspension, refer to the detailed Instructions for Use that comes with IMBRUVICA® oral suspension.
IMBRUVICA® tablets
come in a blister pack
Take one 420-mg IMBRUVICA® tablet by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® tablets blister pack
It contains 28 tablets (a 4-week supply)
Each tablet is identical
Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions
OR
IMBRUVICA® capsules come in a bottle
Take all three 140-mg IMBRUVICA® capsules by mouth at about the same time each day with a glass of water.
Learn more about the IMBRUVICA® capsules bottle
The bottle contains a 30-day supply based on recommended dosing
Each capsule is identical
OR
IMBRUVICA® oral suspension comes in a bottle
Take 6 mL of liquid IMBRUVICA® oral suspension by mouth at about the same time each day. Make sure to drink water after swallowing the dose.
Learn more about the IMBRUVICA® oral suspension bottle
Supplied in a glass bottle with child-resistant screw cap
2 reusable/
washable oral dosing syringes Each mL of liquid oral suspension contains 70 mg of IMBRUVICA®
Tablets and capsules are not shown at actual size. Talk to your doctor about which dosing option is right for you.
Previously treated cGVHD: Children age 1 year to less than 12 years of age
Helpful resources for preparing and dosing liquid IMBRUVICA®
Learn more about the IMBRUVICA® oral suspension bottle
Glass bottle with child-resistant screw cap
2 reusable/washable oral dosing syringes
Dose amount is dependent on the child's weight, height, and age
What you should know about the side effects of IMBRUVICA®
Before taking any medicine, it’s important to understand its benefits and risks. Your doctor can help you understand what to expect before starting treatment with IMBRUVICA® and can address side effects if you experience them.
Your doctor could consider a dose adjustment to manage certain side effects so that you may continue to benefit from treatment, including pausing or reducing your dosage. However, in some cases IMBRUVICA® will need to be stopped permanently.
Take IMBRUVICA® exactly as your doctor instructs.
The most common side effects of IMBRUVICA® in adults with B-cell malignancies (CLL/SLL and WM) include low platelet count; diarrhea; tiredness; muscle, bone, and joint pain; low white blood cell count; rash; low red blood cell count (anemia); bruising; and nausea.
The most common side effects of IMBRUVICA® in adults or children 1 year of age and older with cGVHD include tiredness; low red blood cell count (anemia); bruising; diarrhea; low platelet count; muscle, bone, and joint pain; fever; muscle spasms; mouth sores (stomatitis); bleeding; nausea; stomach pain; pneumonia; and headache.
These are not all the possible side effects of IMBRUVICA®. Please read the full Important Side Effect Information to learn about these and other risks.
Also important to know:
- Take or give IMBRUVICA® exactly as your healthcare provider tells you to take or give it.
- Take or give IMBRUVICA® 1 time a day at about the same time each day.
IMBRUVICA® comes as capsules, tablets, and oral suspension.
-
If your healthcare provider prescribes IMBRUVICA® capsules or tablets:
- Swallow IMBRUVICA® capsules or tablets whole with a glass of water.
- Do not open, break, or chew IMBRUVICA® capsules.
- Do not cut, crush, or chew IMBRUVICA® tablets.
-
If your healthcare provider prescribes IMBRUVICA® oral suspension:
- See the detailed Instructions for Use that comes with IMBRUVICA® oral suspension for information about the correct way to take or give a dose. If you have questions about how to take or give IMBRUVICA® oral suspension, talk to your healthcare provider.
- Do not use if the carton seal is broken or missing.
- If you miss a dose of IMBRUVICA®, take or give it as soon as you remember on the same day. Take or give the next dose of IMBRUVICA® at the regular time on the next day. Do not take or give extra doses of IMBRUVICA® to make up for a missed dose.
- If you take too much IMBRUVICA®, call your healthcare provider or go to the nearest hospital emergency room right away.
Call your doctor or pharmacist if you have any questions.
While taking IMBRUVICA®
- Do not drink grapefruit juice
- Do not eat grapefruit
- Do not eat Seville oranges, often used in marmalade
These products may increase the amount of IMBRUVICA® in your blood.
Storing IMBRUVICA®
- Store IMBRUVICA® capsules and tablets at room temperature between 68°F and 77°F (20°C and 25°C)
- Keep IMBRUVICA® capsules in the original container with the lid tightly closed
- Keep IMBRUVICA® tablets in the original carton
- Store IMBRUVICA® oral suspension bottle between 36°F and 77°F (2°C and 25°C). Do not freeze
- Use IMBRUVICA® oral suspension within 60 days after first opening the bottle. Throw away (discard) any unused portion 60 days after opening
Keep IMBRUVICA® and all medicines out of the sight and reach of children.
Tell your doctor about any other medications you are taking, including prescriptions or over-the-counter medications, vitamins, and herbal supplements. Taking IMBRUVICA® with certain other medicines may affect how IMBRUVICA® works and can cause side effects.
Some ways to stay on track with your treatment2
It’s important to take your medicines exactly as directed by your doctor and creating a routine may help with your IMBRUVICA® treatment. Here are some ways to help you stay on course:
Link it. Take your medicine at the same time as something else you do on a daily basis, like walking the dog or preparing for bed.
Hear it. Set a daily alarm on your phone, watch, or clock to go off when you need to take IMBRUVICA®.
See it. Use reminder notes or put your IMBRUVICA® container in a place you will see it (like on the kitchen counter). Keep IMBRUVICA® out of the reach of children.
Use your tools. Use tools, such as an app on your smartphone, or a calendar, to set reminders for yourself.
Do not stop taking IMBRUVICA® without talking to your doctor. Always take IMBRUVICA® exactly as your doctor prescribes.
References: 1. IMBRUVICA® (ibrutinib) Prescribing Information. 2. MedlinePlus. Taking medicine at home: create a routine. Accessed March 14, 2024. https://medlineplus.gov/ency/patientinstructions/000613.htm