
Taking IMBRUVICA®
You Can Take IMBRUVICA® Anywhere
Once-a-day dosing1
Because IMBRUVICA® is an oral medication, you have the freedom to take it at home or wherever you may be.
- For CLL/SLL
IMBRUVICA® is dosed once a day as either a single 420-mg tablet or three 140-mg capsules. - For WM
IMBRUVICA® is dosed once a day as either a single 420-mg tablet or three 140-mg capsules. - For previously treated cGVHD
IMBRUVICA® is dosed once a day as either a single 420-mg tablet or three 140-mg capsules.

- For previously treated MZL
IMBRUVICA® is dosed once a day as either a single 560-mg tablet or four 140-mg capsules. - For previously treated MCL
IMBRUVICA® is dosed once a day as either a single 560-mg tablet or four 140-mg capsules.
Talk to your doctor about which dosing option is right for you.


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Taking IMBRUVICA® and have questions?
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Tablets and capsules are not shown at actual size.
Taking IMBRUVICA® tablets1
How to take IMBRUVICA® tablets
- Take one IMBRUVICA® tablet by mouth, at about the same time each day, with a glass of water.
About the IMBRUVICA® tablets blister pack
- It contains 28 tablets (a 4-week supply)
- Each tablet is identical
- Blister packs are available in different tablet strengths. Contact your doctor for dosing instructions.
IMBRUVICA® tablets come in a blister pack


Taking IMBRUVICA® capsules1
How to take IMBRUVICA® capsules
- Take your dose of IMBRUVICA® capsules by mouth, at about the same time each day, with a glass of water
About the IMBRUVICA® capsules bottles
- The bottles contain a 30-day supply based on recommended dosing
- Each capsule is identical
IMBRUVICA® capsules come in a bottle

- Do not open, break, or chew capsules.
- Do not cut, crush, or chew tablets.
- If you miss a dose of IMBRUVICA®, take it as soon as you remember on the same day
- Take your next dose of IMBRUVICA® at your regular time on the next day
- Do not take extra doses of IMBRUVICA® to make up for a missed dose
- If you take too much IMBRUVICA®, call your healthcare provider or go to the nearest hospital emergency room right away
- Call your doctor or pharmacist if you have any questions
Tell your doctor about any other medications you are taking, including prescriptions or over-the-counter medications, vitamins, and herbal supplements. Taking IMBRUVICA® with certain other medicines may affect how IMBRUVICA® works and can cause side effects.
Store IMBRUVICA® in its original container at room temperature from 68°F to 77°F
(20°C to 25°C).
While taking IMBRUVICA®1
- Do not drink grapefruit juice
- Do not eat grapefruit
- Do not eat Seville oranges, often used in marmalade
These products may increase the amount of IMBRUVICA® in your blood.
Strategies to help you plan your IMBRUVICA® routine2-6
It’s important to take your medicines exactly as directed by your doctor.
Creating a routine can help you remember. This will help you get the most
benefit from your treatment.

Link it. Take your medicine at the same time as something else you do on a daily basis, like walking the dog or brushing your teeth.

See it. Use reminder notes or put your IMBRUVICA® container in a place you will see it (like next to your bed). Keep IMBRUVICA® out of the reach of children.

Hear it. Set a daily alarm on your phone, watch, or clock to go off when you need to take IMBRUVICA®.

Use your tools. Use tools, such as an app on your smartphone, or a calendar, to set reminders for yourself.
Do not stop taking IMBRUVICA® without talking to your doctor. Always take IMBRUVICA® exactly as your doctor prescribes.
Below you will see a tool you can use to remind you to take your IMBRUVICA® medication once a day, at about the same time every day. Remember to always take your medication exactly as your doctor has prescribed.
Medisafe for IMBRUVICA®
This free smartphone app for iOS or Android can remind you to take IMBRUVICA® exactly as your doctor prescribed. You can sign up to receive customized IMBRUVICA® information, too.

References:
- IMBRUVICA® (ibrutinib) Prescribing Information.
- Borgsteede SD, Westerman MJ, Kok IL, Meeuse JC, de Vries TPGM, Hugtenburg JG. Factors related to high and low levels of drug adherence according to patients with type 2 diabetes. Int J Clin Pharm. 2011;33(5):779-787.
- National Institutes of Health MedlinePlus. Taking medicine at home—create a routine. http://www.nlm.nih.gov/medlineplus/ency/patientinstructions/000613.htm. Published August 25, 2012. Accessed May 7, 2019.
- Ruppar TM, Russell CL. Medication adherence in successful kidney transplant recipients. Prog Transplant. 2009;19(2):167-172.
- Tong A, Howell M, Wong G, Webster AC, Howard K, Craig JC. The perspectives of kidney transplant recipients on medicine taking: a systematic review of qualitative studies. Nephrol Dial Transplant. 2011;26(1):344-354.
- Ryan GW, Wagner GJ. Pill taking "routinization": a critical factor to understanding episodic medication adherence. AIDS Care. 2003;15(6):795-806.