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Surround Yourself with Support

As you move through your treatment journey with IMBRUVICA® (ibrutinib), always keep in touch with your healthcare team and don’t hesitate to ask questions. Your doctors, nurses, and pharmacists all bring specific types of expertise to your care and are ready to answer questions and provide you with support and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) resources.

Stay motivated

You are not alone. Surround yourself with friends, family, and support groups in order to stay motivated. One-on-one peer support programs, such as the Lymphoma Research Foundation’s support network (www.lymphoma.org), match lymphoma survivors and caregivers with volunteers who have gone through similar experiences.

Your family and friends may want to support you, but might not know how. Make sure to tell them exactly how they can help. You might ask a friend or family member to:

  • Be with you at doctor appointments
  • Go grocery shopping for you or with you
  • Do something fun to help you stay positive
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Hear personal stories from patients who are living with CLL/SLL

    Patient Testimonials

    La Verne’s story

    Tina’s story

    Choosing CLL/SLL treatment

    Healthcare Provider Expert & Patient Overviews

    Understanding CLL/SLL

    Understanding IMBRUVICA®

    Resources

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    National Comprehensive Cancer Network® (NCCN®) recommends ibrutinib (IMBRUVICA®)

    NCCN is dedicated to improving the quality of cancer care, so patients can lead better lives. They provide cancer treatment guidelines for use by patients and healthcare providers worldwide.

    NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) recommends ibrutinib (IMBRUVICA®) as a preferred initial treatment for people with CLL/SLL. This includes adults:

    • Of all ages
    • Who are otherwise in good health
    • Who are frail or have significant health conditions

    The NCCN Guidelines for Patients are available for download at nccn.org/patients.

    Talk to your doctor to find out which treatment option is right for you.

    Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma V2.2021. © National Comprehensive Cancer Network, Inc. 2020. All rights reserved. Accessed December 3, 2020. To view the most recent and complete version of the guideline go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

    Stay informed

    Knowledge is empowering—so try to learn all you can about your condition. The websites below are good places to find additional information on CLL/SLL, treatment options, support groups, and resources:

    For more information on CLL/SLL:

    For cancer support communities:

    IMPORTANT SIDE EFFECT INFORMATION

    Before taking IMBRUVICA®, tell your healthcare provider about all of your medical 
    conditions, including if you:

    • have had recent surgery or plan to have surgery. Your healthcare provider may stop IMBRUVICA® for any planned medical, surgical, or dental procedure.
    • have bleeding problems
    • have or had heart rhythm problems, smoke, or have a medical condition that increases your risk of heart disease, such as high blood pressure, high cholesterol, or diabetes
    • have an infection
    • have liver problems
    • are pregnant or plan to become pregnant. IMBRUVICA® can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with IMBRUVICA®. Tell your healthcare provider if you are pregnant or think you may be pregnant during treatment with IMBRUVICA®. 
      • Females who are able to become pregnant should use effective birth control (contraception) during treatment with IMBRUVICA® and for 1 month after the last dose.
      • Males with female partners who are able to become pregnant should use effective birth control, such as condoms, during treatment with IMBRUVICA® and for 1 month after the last dose.
    • are breastfeeding or plan to breastfeed.  Do not breastfeed during treatment with IMBRUVICA® and for 1 week after the last dose. 

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking IMBRUVICA® with certain other medicines may affect how IMBRUVICA® works and can cause side effects.

    How should I take IMBRUVICA®?

    • Take IMBRUVICA® exactly as your healthcare provider tells you to take it.
    • Take IMBRUVICA® 1 time a day.
    • Swallow IMBRUVICA® capsules or tablets whole with a glass of water.
    • Do not open, break or chew IMBRUVICA® capsules.
    • Do not cut, crush or chew IMBRUVICA® tablets.
    • Take IMBRUVICA® at about the same time each day.
    • If you miss a dose of IMBRUVICA® take it as soon as you remember on the same day. Take your next dose of IMBRUVICA® at your regular time on the next day. Do not take extra doses of IMBRUVICA® to make up for a missed dose.
    • If you take too much IMBRUVICA® call your healthcare provider or go to the nearest hospital emergency room right away. 

    What should I avoid while taking IMBRUVICA®?

    • You should not drink grapefruit juice, eat grapefruit, or eat Seville oranges (often used in marmalades) during treatment with IMBRUVICA®. These products may increase the amount of IMBRUVICA® in your blood.

    What are the possible side effects of IMBRUVICA®?

    IMBRUVICA® may cause serious side effects, including:

    • Bleeding problems (hemorrhage) are common during treatment with IMBRUVICA®, and can also be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs of bleeding, including: blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding, or bleeding that is severe or that you cannot control, vomit blood or vomit looks like coffee grounds, cough up blood or blood clots, increased bruising, dizziness, weakness, confusion, change in your speech, or a headache that lasts a long time or severe headache.  
    • Infections can happen during treatment with IMBRUVICA®. These infections can be serious and may lead to death. Tell your healthcare provider right away if you have fever, chills, weakness, confusion, or other signs or symptoms of an infection during treatment with IMBRUVICA®.
    • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with IMBRUVICA®, but can also be severe.  Your healthcare provider should do monthly blood tests to check your blood counts.
    • Heart problems. Serious heart rhythm problems (ventricular arrhythmias, atrial fibrillation, and atrial flutter), heart failure, and death have happened in people treated with IMBRUVICA®, especially in people who have an increased risk for heart disease, have an infection, or who have had heart rhythm problems in the past. Tell your healthcare provider if you get any symptoms of heart problems, such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, swelling of the feet, ankles, or legs, chest discomfort, or you faint.  If you develop any of these symptoms, your healthcare provider may do a test to check your heart (ECG) and may change your IMBRUVICA® dose.
    • High blood pressure (hypertension). New or worsening high blood pressure has happened in people treated with IMBRUVICA®. Your healthcare provider may start you on blood pressure medicine or change current medicines to treat your blood pressure.
    • Second primary cancers. New cancers have happened during treatment with IMBRUVICA®, including cancers of the skin or other organs.
    • Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer cells. TLS can cause kidney failure and the need for dialysis treatment, abnormal heart rhythm, seizure, and sometimes death. Your healthcare provider may do blood tests to check you for TLS.

    The most common side effects of IMBRUVICA® in adults with B-cell malignancies (MCL, CLL/SLL, WM and MZL) include:

    • diarrhea
    • tiredness
    • muscle and bone pain
    • rash
    • bruising

    The most common side effects of IMBRUVICA® in adults with cGVHD include:

    • tiredness
    • bruising
    • diarrhea
    • mouth sores (stomatitis)
    • muscle spasms
    • nausea
    • pneumonia

    Diarrhea is a common side effect in people who take IMBRUVICA®. Drink plenty of fluids during treatment with IMBRUVICA® to help reduce your risk of losing too much fluid (dehydration) due to diarrhea. Tell your healthcare provider if you have diarrhea that does not go away.

    These are not all the possible side effects of IMBRUVICA®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    General information about the safe and effective use of IMBRUVICA®

    Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use IMBRUVICA® for a condition for which it was not prescribed. Do not give IMBRUVICA® to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about IMBRUVICA® that is written for health professionals.

    Please see the full Important Product Information.

    USES

    What is IMBRUVICA® (ibrutinib)?

    IMBRUVICA® (ibrutinib) is a prescription medicine used to treat adults with: 

    • Mantle cell lymphoma (MCL) who have received at least one prior treatment
    • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
    • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) with 17p deletion
    • Waldenström’s macroglobulinemia (WM)
    • Marginal zone lymphoma (MZL) who require a medicine by mouth or injection (systemic therapy) and have received a certain type of prior treatment
    • Chronic graft versus host disease (cGVHD) after failure of 1 or more lines of systemic therapy

    It is not known if IMBRUVICA® is safe and effective in children.

    IMPORTANT SIDE EFFECT INFORMATION

    USES