What Is Chronic Lymphocytic Leukemia? What Is Chronic Lymphocytic Leukemia?


IMBRUVICA® (ibrutinib) is an oral, once-daily therapy

Understanding Mantle Cell Lymphoma (MCL)

Mantle cell lymphoma (MCL) may seem overwhelming at first, but understanding it can help you feel more at ease.

Learn how IMBRUVICA® works
In MCL, the abnormal B cells crowd out healthy B cells.

MCL is a type of B cell non-Hodgkin lymphoma, a cancer of the immune system. In MCL, abnormal B cells grow out of control and may crowd out healthy B cells in the lymph nodes, bone marrow, and other organs. The name Mantle Cell Lymphoma comes from the fact that the abnormal B cells originate in the mantle zone (the outer edge) of the lymph node.1,2

Your doctor will make sure you have routine blood tests, such as a complete blood count (CBC) or total protein level, to get a more detailed picture of your condition. This will help you and your doctor make a plan for your treatment.

What are the most common Mantle Cell Lymphoma symptoms?2

  • Swollen lymph nodes

  • An enlarged spleen (you may experience abdominal fullness/bloating)

  • Low red blood cell count or anemia (leading to fatigue)

  • Low platelet count (associated with bruising and bleeding)

  • Decrease in white blood cells (increasing risk for infection)

  • GI disturbances—nausea, vomiting, and loss of appetite

  • “B” symptoms: fever, night sweats, and significant weight loss

Read more about MCL


Want to learn more about MCL?


Read the brochure for patients with MCL

IMBRUVICA® has helped many people with previously treated MCL

In a clinical trial of 111 people with previously treated MCL4

  • 65.8% had a response to IMBRUVICA®. In other words, their doctor observed fewer signs of the disease as seen through X-rays, CT scans, and/or bone marrow tests4

  • This response continued for a median* of 17.5 months4

*Median is the middle number in a group of numbers that are arranged from lowest to highest. For example, in the group of numbers 1-11, 6 is the median.


What should I know about IMBRUVICA® side effects?

IMBRUVICA® may cause serious side effects, including4:

  • Bleeding problems

  • High blood pressure (hypertension)

  • Infections

  • Second primary cancers

  • Decrease in blood cell counts

  • Tumor lysis syndrome

  • Heart rhythm problems (atrial fibrillation and atrial flutter)

The most common side effects in the MCL clinical trial were4:

  • Low blood platelet count

  • Nausea

  • Diarrhea

  • Bruising

  • Low white blood cell count

  • Shortness of breath

  • Low red blood cell count

  • Constipation

  • Tiredness

  • Rash

  • Muscle and bone pain

  • Stomach (abdomen) pain

  • Swelling of legs and feet

  • Vomiting

  • Upper respiratory tract infection

  • Decreased appetite

In the clinical trial, 9% of MCL patients stopped taking the drug because of side effects.4

This is not a complete list of side effects. Others may occur. Tell your doctor if you think you are experiencing side effects.


References: 1. National Cancer Institute. NCI Dictionary of Cancer Terms. Accessed September 25, 2015. 2. Leukemia and Lymphoma Society (LSS) (2012) Fact Sheet 4: Mantle Cell Lymphoma. 3. American Cancer Society. Non-Hodgkin Lymphoma. Atlanta, GA: American Cancer Society, 2014. 4. IMBRUVICA® (ibrutinib) Prescribing Information. Pharmacyclics LLC. 2016.


You are now leaving

By clicking "OK" below you will be taken to a website that may contain links or references to other websites to which our Privacy Policy may not apply. We encourage you to read the Privacy Policy of every website you visit.

For any questions about the Pharmacyclics Privacy Policy, please visit


Are you a healthcare professional?

You are leaving the patient and caregiver site and entering the US Healthcare professional site. The information contained in this site is intended for US healthcare professionals only. Click “OK” below if you are a healthcare professional.



What should I tell my healthcare provider before taking IMBRUVICA®?

Before you take IMBRUVICA®, tell your healthcare provider about all of your medical conditions, including if you:

  • Have had recent surgery or plan to have surgery. Your healthcare provider may stop IMBRUVICA® for any planned medical, surgical, or dental procedure
  • Have bleeding problems
  • Have or had heart rhythm problems, smoke, or have a medical condition that increases your risk of heart disease, such as high blood pressure, high cholesterol, or diabetes
  • Have an infection
  • Have liver problems
  • Are pregnant or plan to become pregnant. IMBRUVICA® can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with IMBRUVICA®
    • Females should not become pregnant during treatment and for 1 month after the last dose of IMBRUVICA®
    • Males should avoid getting female partners pregnant during treatment and for 1 month after the last dose of IMBRUVICA®
  • Are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will take IMBRUVICA® or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking IMBRUVICA® with certain other medicines may affect how IMBRUVICA® works and can cause side effects.

How should I take IMBRUVICA®?

  • Take IMBRUVICA® exactly as your healthcare provider tells you to take it
  • Take IMBRUVICA® 1 time a day
  • Swallow IMBRUVICA® capsules whole with a glass of water. Do not open, break, or chew IMBRUVICA® capsules
  • Take IMBRUVICA® at about the same time each day
  • If you miss a dose of IMBRUVICA® take it as soon as you remember on the same day. Take your next dose of IMBRUVICA® at your regular time on the next day. Do not take 2 doses of IMBRUVICA® on the same day to make up for a missed dose
  • If you take too much IMBRUVICA®, call your healthcare provider or go to the nearest hospital emergency room right away

What should I avoid while taking IMBRUVICA®?

  • You should not drink grapefruit juice, eat grapefruit, or eat Seville oranges (often used in marmalades) during treatment with IMBRUVICA®. These products may increase the amount of IMBRUVICA® in your blood

What are the possible side effects of IMBRUVICA®?

IMBRUVICA® may cause serious side effects, including:

  • Bleeding problems can happen during treatment with IMBRUVICA® that can be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs of bleeding, including: blood in your stools or black stools (looks like tar), pink or brown urine, unexpected bleeding or bleeding that is severe or that you cannot control, vomit blood or vomit looks like coffee grounds, cough up blood or blood clots, increased bruising, dizziness, weakness, confusion, change in your speech, or a headache that lasts a long time
  • Infections can happen during treatment with IMBRUVICA®. These infections can be serious and may lead to death. Tell your healthcare provider right away if you have fever, chills, weakness, confusion, or other signs or symptoms of an infection during treatment with IMBRUVICA®
  • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with IMBRUVICA®, but can also be severe. Your healthcare provider should do monthly blood tests to check your blood counts
  • Heart rhythm problems (atrial fibrillation and atrial flutter). Heart rhythm problems have happened in people treated with IMBRUVICA®, especially in people who have an increased risk for heart disease, have an infection, or who have had heart rhythm problems in the past. Tell your healthcare provider if you get any symptoms of heart rhythm problems, such as feeling as if your heart is beating fast and irregular, lightheadedness, dizziness, shortness of breath, chest discomfort, or you faint
  • High blood pressure (hypertension). New or worsening high blood pressure has happened in people treated with IMBRUVICA®. Your healthcare provider may start you on blood pressure medicine or change current medicines to treat your blood pressure
  • Second primary cancers. New cancers have happened in people who have been treated with IMBRUVICA®, including cancers of the skin or other organs
  • Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer cells. TLS can cause kidney failure and the need for dialysis treatment, abnormal heart rhythm, seizure, and sometimes death. Your healthcare provider may do blood tests to check you for TLS

The most common side effects of IMBRUVICA® include: diarrhea, muscle and bone pain, rash, nausea, bruising, tiredness, and fever.

Diarrhea is a common side effect in people who take IMBRUVICA®. Drink plenty of fluids during treatment with IMBRUVICA® to help reduce your risk of losing too much fluid (dehydration) due to diarrhea. Tell your healthcare provider if you have diarrhea that does not go away.

General information about the safe and effective use of IMBRUVICA®

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use IMBRUVICA® for a condition for which it was not prescribed. Do not give IMBRUVICA® to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about IMBRUVICA® that is written for health professionals.

These are not all the possible side effects of IMBRUVICA®. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please review the full Important Product Information.


What is IMBRUVICA® (ibrutinib)?

IMBRUVICA® (ibrutinib) is a prescription medicine used to treat people with:

  • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
  • Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) with 17p deletion
  • Waldenström's macroglobulinemia (WM)
  • Mantle cell lymphoma (MCL) who have received at least one prior treatment
    • For MCL, IMBRUVICA® is approved on response. Data are not yet available to show if IMBRUVICA® improves survival or symptoms

It is not known if IMBRUVICA® is safe and effective in children.

Your use of the information on this site is subject to the terms of the Legal Notice and Privacy Policy of Pharmacyclics LLC. This site is published by Pharmacyclics LLC which has developed the content in conjunction with Janssen Biotech, Inc. Any information that is collected on this site may be shared between Pharmacyclics LLC and Janssen Biotech, Inc. This information is intended for use by our customers, patients, and healthcare professionals in the United States only. Pharmacyclics LLC recognizes that the Internet is a global communication medium; however laws, regulatory requirements, and medical practices vary from country to country.

IMBRUVICA® (ibrutinib) capsules are covered by U.S. Pat. Nos. 7,514,444; 8,008,309; 8,497,277; 8,476,284; 8,697,711 and 8,703,780.

© Pharmacyclics LLC. 2016

© Janssen Biotech, Inc. 2016

07/16 PRC-01907